Basic Information
VIS ID
TVIS30001404
Fusion event
HIV-PPP2R5C integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.31
Reference genome
GRCh37/hg19
Start
102381491/101915154 (Hg38)
End
102381606/101915154 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP2R5C
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-31-3p ; hsa-mir-135b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-1277-5p ; hsa-mir-3190-3p ; hsa-mir-3607-5p ; hsa-mir-3611 ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-6505-5p ; hsa-mir-6833-5p ; hsa-mir-6838-5p ; hsa-mir-7114-5p ; hsa-mir-29c-5p ; hsa-mir-4680-5p ; hsa-mir-134-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-3664-5p ; hsa-mir-548ao-3p ; hsa-mir-193b-3p ; hsa-mir-193a-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/354732; hsa-mir-12121/Downstream/624490;
Nearest TSS
ENST00000550708/Upstream/5506; ENST00000554147/Downstream/2615;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/23390, chr14-CpG: 26/Downstream/10108
Nearest cancer related gene
PPP2R5C(TSG, No orient, 0)
Target sequence
CAACCTCCGCCTCCCAGGTTCAAGCAGTCCTCCGGAGTGCCTCAGCCTCCCAAGTATGCTGGGACTACAGGTGCACGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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