Basic Information
VIS ID
TVIS30001411
Fusion event
HIV-SF3B2 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65829975/66062504 (Hg38)
End
65830650/66062504 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
SF3B2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-342-3p ; hsa-mir-3189-3p
Nearest miRNA
hsa-mir-10392/Upstream/413251; hsa-let-7a-2/Downstream/871930;
Nearest TSS
ENST00000527297/Upstream/1813; ENST00000534765/Downstream/2137;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9751, chr11-CpG: 139/Downstream/7279
Target sequence
AAACCAACAATCTAACCTTCATGACATTAAGTAAAACCAAGATCGCTAGTACATGGCCCATACCTGAAATTCAGCAGCATTGGTTCCAAACACGTCCCCATAGAGCGGTTTCCCAGTCTCATCCACTGGAGGTTTGCCCCAGCCACCAGCATGGTACCCAAAGGAACAGCTCTGCAAGACAGTGAGCACAATCAGTTCACTCCTTAGCTGCAAAAGAAATTCTGAAGCCCTAGAGAAAAGGCACACTCAAAAGTA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate