VISDB - VIS Detail

Basic Information

VIS ID

TVIS30001414

Fusion event

HIV-SPC25 integration

Validated

Yes

Detection method

QiaQuick PCR and Sequencing

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

25011556

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr2

Cytoband

q24.3

Reference genome

GRCh37/hg19

Start

169735181/168878671 (Hg38)

End

169736066/168878671 (Hg38)

Orient

Location type

Intronic

Target gene

SPC25

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-26b-5p ; hsa-mir-3674 ; hsa-mir-135b-3p ; hsa-mir-7156-3p ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-8065 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-3121-5p ; hsa-mir-3914 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-5582-3p ; hsa-mir-548a-5p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-8084

Nearest miRNA

hsa-mir-128-1/Upstream/295653; hsa-mir-10b/Downstream/6288962;

Nearest TSS

ENST00000437798/Upstream/19562; ENST00000429379/Downstream/10622;

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/421559, chr2-CpG: 22/Downstream/11538

Target sequence

GGTACTACACCCCAAAAAAATCAATAGTTTTTGTACATAACACCAGTGATTAATACATAGGTAAGAATAGATGTTTATACTAATATTAATAGCTGCAATATTCGTTTTTGTTCTTTGTTTTTATTGGTTTTATTAGTTTTTGCTATTCTGTGCTATTTTTAAGTACTGGCATACGTTGGAGATATTGCAAGTTCTATTCCAGATCACTGTGATAAAGCGAATATTGCCATAAAGCAAGTCACACAAATGTTTTGG

Reference

Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.