Basic Information
VIS ID
TVIS30001420
Fusion event
HIV-TIAM1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
32540916/31168599 (Hg38)
End
32541240/31168599 (Hg38)
Orient
+
Location type
Intronic
Target gene
TIAM1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-31-5p ; hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-221-3p ; hsa-let-7b-5p ; hsa-mir-10b-5p ; hsa-mir-329-3p ; hsa-mir-141-3p ; hsa-mir-10a-5p ; hsa-mir-342-3p ; hsa-mir-29c-3p ; hsa-mir-22-3p ; hsa-mir-182-5p
Nearest miRNA
hsa-let-7c/Upstream/793221; hsa-mir-3197/Downstream/2382063;
Nearest TSS
ENST00000624081/Upstream/7690; ENST00000433071/Downstream/175680;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1228811, chr21-CpG: 24/Downstream/83229
Target sequence
CCATGTTAGCCAGGATGGTCTCGATCTCCTAACCTCGTGATCCACCTGTCTTGGCCTCCCCAAGTGCTAGGATTACAGGTGTAAGCCACTGTGCCAGGCCCCCTGACATTCTAATCATAGGACTGACTTCATGTGTTTGTATTCCAAGGCATCTGGTAGGAGCAAAAACAAATCTACTCTGGTAGAATTCACTCTTAATGATGATATCATATAATACCCAGAGATAGAGCTTGGTCAAAGAAGAACCCATAATCC
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Curate