Basic Information
VIS ID
TVIS30001421
Fusion event
HIV-TICAM1 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4821656/4821644 (Hg38)
End
4821881/4821644 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
TICAM1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-193b-3p
Nearest miRNA
hsa-mir-1227/Upstream/50865; hsa-let-7e/Downstream/111043;
Nearest TSS
ENST00000633603/Upstream/3674; ENST00000591657/Downstream/10060;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/28439, chr19-CpG: 43/Downstream/9777
Target sequence
GAGTTCAAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAACCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGATGAGGCAGAAGAATCGCTAGAACCCGGGAGGCGGAGGTTGCGGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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