Basic Information
VIS ID
TVIS30001423
Fusion event
HIV-TSKS integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50246122/49742865 (Hg38)
End
50246354/49742865 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
TSKS
Nearest miRNA
hsa-mir-10395/Upstream/60670; hsa-let-7e/Downstream/49001;
Nearest TSS
ENST00000633603/Upstream/2534; ENST00000600199/Downstream/4513;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/22743, chr19-CpG: 34/Downstream/3370
Target sequence
ATAATACACTAGTGAAACTCGATTTCATGTTGTACTGTGAGTCCCCCTTTCCTACAATGGACCTTCCCACAATGGGCCAAAAATGGTGTATCCCTCGGCTCTCACAATACACCAAGGTCTCACTTCCCCCTCAGTGCACTGAAACCCTGCCTCTCCTCATGTTCACATCCCAGCCTTCCCACAATGCACTGGAAATATGATGCTTAAAATGTACTAAGTGTTTTTTTTTTTT
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
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