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VISDB
Viral Integration Site DataBase
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TVIS30001434
Basic Information
VIS ID
TVIS30001434
Fusion event
HIV-ZNF253 integration
Validated
Yes
Detection method
QiaQuick PCR and Sequencing
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
25011556
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
19995761/19884952 (Hg38)
End
19996530/19884952 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF253
miRNAs that regulate target gene
hsa-mir-296-3p
;
hsa-mir-4776-3p
;
hsa-mir-7152-5p
;
hsa-mir-3074-5p
;
hsa-mir-4715-3p
;
hsa-mir-3064-3p
;
hsa-mir-3124-3p
;
hsa-mir-1914-5p
;
hsa-mir-3163
;
hsa-mir-570-5p
;
hsa-mir-548ba
;
hsa-mir-548ai
;
hsa-mir-548ag
;
hsa-mir-376b-3p
;
hsa-mir-376a-3p
;
hsa-mir-23c
;
hsa-mir-23b-3p
;
hsa-mir-23a-3p
;
hsa-mir-130a-5p
;
hsa-mir-4262
;
hsa-mir-181d-5p
;
hsa-mir-181c-5p
;
hsa-mir-181b-5p
;
hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10395/Upstream/449794; hsa-let-7e/Downstream/514320;
Nearest TSS
ENST00000633603/Upstream/6471;
ENST00000592613/Downstream/10895;
Nearest CpG islands
None/Target,
chr19-CpG: 112/Upstream/23898
,
chr19-CpG: 25/Downstream/16149
Target sequence
CTAACAAATATTTTAGAAAAAATACAAAACAAGCCGGGCACGGTGGCTGATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTATTAAAAATACAAAAAACTTAGCCGGGCATGGTGGCGGGCGCCCATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGAAGGCAGAGCTTGCA
Reference
Wagner, T. A., et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science,2014, 345(6196): 570-573.
Sample Information
×
Sample name
R1
Sample type
PBMC
Gender
Female
CpG Island Information
×
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