Basic Information
VIS ID
TVIS30001461
Fusion event
HIV-MTOR integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
11282927/11222870 (Hg38)
End
11282927/11222870 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MTOR
miRNAs that regulate target gene
hsa-mir-99a-5p ; hsa-mir-520c-3p ; hsa-mir-373-3p ; hsa-mir-99b-5p ; hsa-mir-144-3p ; hsa-mir-100-5p ; hsa-mir-199a-3p ; hsa-mir-16-5p ; hsa-mir-744-5p ; hsa-mir-181b-5p ; hsa-mir-101-3p ; hsa-let-7c-5p ; hsa-mir-218-5p ; hsa-mir-496 ; hsa-mir-196b-5p ; hsa-mir-224-5p ; hsa-mir-128-3p ; hsa-mir-193a-5p ; hsa-mir-125a-5p ; hsa-mir-497-5p ; hsa-mir-3188
Nearest miRNA
hsa-mir-12136/Upstream/1255412; hsa-mir-101-1/Downstream/806288;
Nearest TSS
ENST00000473358/Upstream/29243; ENST00000376810/Downstream/39637;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/122791, chr1-CpG: 60/Downstream/39331
Nearest cancer related gene
MTOR(OG, No orient, 0)
Upstream sequence
aaaatatatatataagtaagaaaatcaccattttgcagtccctaatcaaataacagctctaggaaataactaccaatgaatgctaaaatgactgggaaaa
Downstream sequence
aggctgatagggaactttataacagatggatcagatgacaatatccgaacccactgatcagcctttacatcactagcagtgggtcatatggaaaatatct
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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