Basic Information
VIS ID
TVIS30001785
Fusion event
HIV-FAS integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
GRCh37/hg19
Start
90753982/88994225 (Hg38)
End
90753982/88994225 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
FAS
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-146a-5p ; hsa-mir-106a-5p ; hsa-mir-504-5p ; hsa-mir-98-5p ; hsa-mir-196b-5p ; hsa-mir-23a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-92a-2-5p ; hsa-mir-92a-1-5p ; hsa-mir-18a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-133b ; hsa-mir-320a
Nearest miRNA
hsa-mir-1265/Upstream/1490271; hsa-mir-107/Downstream/69110;
Nearest TSS
ENST00000439456/Upstream/2777; ENST00000640140/Downstream/8355;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2842, chr10-CpG: 42/Downstream/213573
Nearest cancer related gene
FAS(TSG, No orient, 0)
Upstream sequence
AATTTCCTTCTGAATACTCTTATACTGACACATAGGAGAAGTGTCAGTGTTTCAAAGGAATCTCTTTGAAGGCTACTACATTGCTTTAGGGGTGCCAGAT
Downstream sequence
TACCAGAGTAAACTGCCAGTTTGAGAGAATAACTGTTTCTTAAGAGATGGTCTGAAACCTAAGTAAGGAAATCCCCCCACTTGAAAGCCCCTAGGAAGTT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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