Basic Information
VIS ID
TVIS30001819
Fusion event
HIV-SIRT3 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
227489/227489 (Hg38)
End
227489/227489 (Hg38)
Orient
-
Location type
Intronic
Target gene
SIRT3
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-1247-3p ; hsa-mir-302a-5p ; hsa-mir-3160-3p ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-495-5p ; hsa-mir-558 ; hsa-mir-5694 ; hsa-mir-6087 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-6743/Upstream/18083; hsa-let-7a-2/Downstream/340600;
Nearest TSS
ENST00000527297/Upstream/14040; ENST00000534590/Downstream/3203;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/18264, chr11-CpG: 101/Downstream/8429
Nearest cancer related gene
SIRT3(TSG, No orient, 0)
Upstream sequence
atcataccactgcactccagcctgggcaacagagcaagactctatctcaaaaaaacaaaaaatccaaacaacaacaacaaaAATAAAACAGGCAGAGAAC
Downstream sequence
AGATAGCaacagtttcagaaatttatatgaaaagccaaaagattcagaccagccaacacagtactgaaggagaagaacaaaggtggggaattaacatcaa
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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