Basic Information
VIS ID
TVIS30001942
Fusion event
HIV-TMEM135 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
86939042/87228000 (Hg38)
End
86939042/87228000 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11F
Target gene
TMEM135
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-196a-5p ; hsa-let-7d-5p ; hsa-mir-1261 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-190a-3p ; hsa-mir-4536-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-6502-3p ; hsa-mir-186-5p ; hsa-mir-1252-5p ; hsa-mir-3159 ; hsa-mir-541-5p ; hsa-mir-610 ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-10392/Upstream/949602; hsa-let-7a-2/Downstream/948502;
Nearest TSS
ENST00000527297/Upstream/156483; ENST00000528861/Downstream/90135;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/189949, chr11-CpG: 45/Downstream/947075
Upstream sequence
CTTTAAATAGAAACTAACATTATAAAAACTCTTATTATCAATAACGTATCTACGTATGTGGTTCTAAAAGACTCTGCCCTCTGGGACTTTGTGTTCTAAG
Downstream sequence
TAAGTAAGAGTTATAAAGAAAGTATACAAACAACACCAAAACCATTGCTTAAATGtattaaataattaaaataacaatataatCAGATGTTTTGGTGAGT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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