Basic Information
VIS ID
TVIS30001978
Fusion event
HIV-CBL integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
119122239/119251529 (Hg38)
End
119122239/119251529 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
CBL
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-150-5p ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-188-3p ; hsa-mir-218-5p ; hsa-mir-1273d ; hsa-mir-7973 ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1224-3p ; hsa-mir-1306-5p ; hsa-mir-216a-5p ; hsa-mir-124-3p ; hsa-mir-1972 ; hsa-mir-3150b-3p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4693-3p ; hsa-mir-4717-5p ; hsa-mir-4784 ; hsa-mir-5192 ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-10392/Upstream/340742; hsa-let-7a-2/Downstream/61421;
Nearest TSS
ENST00000527297/Upstream/45105; ENST00000634301/Downstream/46843;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/44685, chr11-CpG: 19/Downstream/59157
Nearest cancer related gene
CBL(TSG, No orient, 0)
Upstream sequence
TCTGTTTTGTTTGAATGTAAAGGAATGGTGACTGTTTCATTTCATATTACAGAAGTGATTCTTTGGAGGCCATACTTCAAACATCATATAAAGTAGTAAA
Downstream sequence
CTACATAAATTTAAGAGAAGTTACACATGTCTTAATAACCTAATAACCATGCCTTTTGGACACAAAAATATTCAGTAGTGTGATTTACAGCAGGATTATA
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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