Basic Information
VIS ID
TVIS30003991
Fusion event
HIV-EGFR integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55130471/55062778 (Hg38)
End
55130471/55062778 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
EGFR
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-7-5p ; hsa-mir-145-5p ; hsa-mir-128-3p ; hsa-mir-146a-5p ; hsa-mir-21-5p ; hsa-mir-542-5p ; hsa-mir-128b ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-27a-3p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-let-7a-5p ; hsa-mir-301b-3p ; hsa-mir-574-3p ; hsa-mir-219a-5p ; hsa-mir-302b-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-2861 ; hsa-mir-132-3p ; hsa-mir-875-5p ; hsa-mir-7-1-3p ; hsa-mir-491-5p ; hsa-mir-27b-3p ; hsa-mir-27a-5p ; hsa-mir-125b-5p ; hsa-mir-3622b-5p ; hsa-mir-520b ; hsa-mir-520e ; hsa-mir-133a-5p ; hsa-mir-146b-5p ; hsa-mir-1-5p ; hsa-mir-137 ; hsa-mir-122-5p ; hsa-mir-200a-3p ; hsa-mir-135a-5p
Nearest miRNA
hsa-mir-1183/Upstream/10180978; hsa-mir-10399/Downstream/1893007;
Nearest TSS
ENST00000635602/Upstream/43627; ENST00000450046/Downstream/46945;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/42366, chr7-CpG: 120/Downstream/191691
Nearest cancer related gene
EGFR(OG, No orient, 0)
Upstream sequence
GAAGGTGGTCCTGGGGGCTGTTCTGAATTCTCAGTTTCCTTTTTTCCCCTCCCCAGTTCTTTGAAAATATCAGAAACGGACTTGTGGCATCTTTGAAAAG
Downstream sequence
CTACTTAAAATGTGCTGCTGTGCTCTGAACTTGAAAATGTGCTTTTAATACAAAGTTTGTGCAGCCCTTGCTGCTCATACGAGATGAATCTtaccatgtg
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
Curate