Basic Information
VIS ID
TVIS30003993
Fusion event
HIV-GTF2I integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
74091635/74677311 (Hg38)
End
74091635/74677311 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
GTF2I
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/81285; hsa-mir-10399/Downstream/1237886;
Nearest TSS
ENST00000635602/Upstream/19280; ENST00000432143/Downstream/7346;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/18559, chr7-CpG: 124/Downstream/110678
Upstream sequence
CAGCTGATTGAACTACTAGTATTAGATCTTTTGGATTTATTTTAAGCACTATTTTAGGACAAAATATCTAACATTTTACTTGATGAATTTTAACTTTTTC
Downstream sequence
TTACCACTCATTGTTTTGAAGAAATTACTTTGTAAAAGTTTGAGATGTCACTAATTTTTCCCTTGGCATTAAGCGATACATGAATTCATTTTATTCTTCT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
Curate