Basic Information
VIS ID
TVIS30009462
Fusion event
HIV-ACTR3B integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.2
Reference genome
GRCh37/hg19
Start
152534844/152837759 (Hg38)
End
152534844/152837759 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ACTR3B
miRNAs that regulate target gene
hsa-mir-379-3p ; hsa-mir-487a-3p ; hsa-mir-539-3p ; hsa-mir-127-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-4710 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-621 ; hsa-mir-4660 ; hsa-mir-6804-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-5690 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-10399/Upstream/1404120; hsa-mir-153-2/Downstream/4736577;
Nearest TSS
ENST00000635602/Upstream/27017; ENST00000462622/Downstream/574475;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/77333, chr7-CpG: 21/Downstream/56216
Upstream sequence
ACATTTTAGGAATGAGAGGCAGACTCTCAACCATGTCATTTTCTCAGAGAAAATTGGATTGTGTGTTGGTAATAACGGTACCTGTCACACTGAGAAATGG
Downstream sequence
TTTGTCGTAGGCATGGCTGAGAGGCTTCAAACCGACTTTGTTGTGGTTTGCTCTCTAATTTATTTCTTATGTTTTCAAGCACCAGGAAAGGGATGCTGAC
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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