Basic Information
VIS ID
TVIS30009687
Fusion event
HIV-JAK2 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5045491/5045491 (Hg38)
End
5045491/5045491 (Hg38)
Orient
+
Location type
Intronic
Target gene
JAK2
miRNAs that regulate target gene
hsa-mir-135a-5p ; hsa-mir-375 ; hsa-mir-335-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-101-3p ; hsa-mir-8485 ; hsa-mir-548as-3p ; hsa-mir-568 ; hsa-mir-5692a ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-216a-5p ; hsa-mir-204-5p
Nearest miRNA
hsa-mir-101-2/Upstream/195116; hsa-let-7a-1/Downstream/962335;
Nearest TSS
ENST00000422679/Upstream/60246; ENST00000519308/Downstream/68058;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/2221, chr9-CpG: 107/Downstream/65293
Nearest cancer related gene
JAK2(OG, No orient, 0)
Upstream sequence
CTTTAtttttattgtggtaagagatatataataaaaatgaccattttaaccattttaagtgtacagttcagttgtattaagtacaaatacattgctgtac
Downstream sequence
aaccatcaccaccatccatctccagaacatttttcatcttcccaaatggaaacttcatacccattaaataataactctgtatttcccactcccaatggcc
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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