Basic Information
VIS ID
TVIS30010160
Fusion event
HIV-MGMT integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
131405398/129607134 (Hg38)
End
131405398/129607134 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
MGMT
miRNAs that regulate target gene
hsa-mir-181d-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-648 ; hsa-mir-767-3p ; hsa-mir-370-3p ; hsa-mir-661 ; hsa-mir-409-3p ; hsa-mir-124-3p ; hsa-mir-127-3p
Nearest miRNA
hsa-mir-107/Upstream/3787312; hsa-mir-202/Downstream/236165;
Nearest TSS
ENST00000439456/Upstream/139872; ENST00000462672/Downstream/94044;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/139688, chr10-CpG: 25/Downstream/172052
Upstream sequence
TGCCCTATGGTAGCTTCACAAGAGTTCTGAGTTGGCACCCTCCGGTTTGGGAGGTAGGTGGAGATGGCTTTGACTTTTGTTCAACTTACAAGGGAGTAAC
Downstream sequence
TTCTTGGAAGTGCAGTCCGGGCCAGCAGAAATGGTCATAGTAGGCCATGGTGGAAGGAGAATCAGAACCACGCGTAAATCCTCAGAAGGAAGAGGGCAGT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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