Basic Information
VIS ID
TVIS30010258
Fusion event
HIV-TBK1 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
64874642/64480862 (Hg38)
End
64874642/64480862 (Hg38)
Orient
-
Location type
Intronic
Target gene
TBK1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-200c-3p ; hsa-mir-452-5p ; hsa-let-7f-2-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-6792-5p ; hsa-mir-3671 ; hsa-mir-3674 ; hsa-mir-219b-3p ; hsa-mir-4680-3p ; hsa-mir-429 ; hsa-mir-4724-5p ; hsa-mir-200b-3p ; hsa-mir-219a-2-3p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-203a-3p
Nearest miRNA
hsa-let-7i/Upstream/657135; hsa-mir-1178/Downstream/141647;
Nearest TSS
ENST00000382841/Upstream/27961; ENST00000545025/Downstream/3179;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28328, chr12-CpG: 132/Downstream/129151
Upstream sequence
GGTATTTAGTATCTGTGATTACTGAATTAGCTTCCATTTTTCTTGAGTGTGGTAGTTATATAATCCTTAATTGGACACAAGTTATGAATTAGTGGCTTAT
Downstream sequence
CACCTTTTTTAAGTTGTGGGTGCTTTTTGTATGACtttaaataaataaatatataaaaCAAGCTAATAAAATATCACTTATCATTTTATATGTTGGGTTC
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
Curate