Basic Information
VIS ID
TVIS30010611
Fusion event
HIV-AKT2 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
40757741/40251834 (Hg38)
End
40757741/40251834 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
AKT2
miRNAs that regulate target gene
hsa-mir-184 ; hsa-mir-203a-3p ; hsa-mir-708-5p ; hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-1296-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-612 ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-137 ; hsa-let-7g-5p ; hsa-let-7b-5p ; hsa-mir-302b-3p ; hsa-mir-1273e ; hsa-mir-92b-5p ; hsa-mir-151b ; hsa-mir-151a-5p ; hsa-mir-3678-5p ; hsa-mir-7845-5p ; hsa-mir-4517 ; hsa-mir-4753-5p ; hsa-mir-6768-3p ; hsa-mir-126-3p ; hsa-mir-2861 ; hsa-mir-148a-5p ; hsa-mir-143-3p
Nearest miRNA
hsa-mir-10395/Upstream/422032; hsa-let-7e/Downstream/30709;
Nearest TSS
ENST00000633603/Upstream/7707; ENST00000600479/Downstream/3343;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/25076, chr19-CpG: 89/Downstream/32996
Nearest cancer related gene
AKT2(OG, No orient, 0)
Upstream sequence
gataaggagaagttactagtaaacaaagattataatcatctcaggcgtgacagcatcatgattctgtaggagaaagtccttattcttaggagatgcctgc
Downstream sequence
tgaaacactaagaatgtcactaagtatgaacacaagttcaagttcagcataaaacacaaccagatgaagcagacacggtgaatgcgggactgcagagtct
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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