Basic Information
VIS ID
TVIS30011016
Fusion event
HIV-CFTR integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
117197905/117557851 (Hg38)
End
117197905/117557851 (Hg38)
Orient
+
Location type
Intronic
Target gene
CFTR
miRNAs that regulate target gene
hsa-mir-433-3p ; hsa-mir-509-3p ; hsa-mir-335-5p ; hsa-mir-132-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-494-3p ; hsa-mir-223-3p ; hsa-mir-145-5p
Nearest miRNA
hsa-mir-10525/Upstream/537532; hsa-mir-10399/Downstream/9500237;
Nearest TSS
ENST00000635602/Upstream/77756; ENST00000472848/Downstream/1787;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/130239, chr7-CpG: 92/Downstream/315037
Nearest cancer related gene
CFTR(TSG, No orient, 0)
Upstream sequence
tgtctcttttagttagcataaagttaggtttgtctttaatttcacctgaagtcttttcctcttaatagatgggttaagccAACTGAAAAATAAAACTGAC
Downstream sequence
TTATATACTTTTATTTCAAGTATGTCCTCCACAAATATTTTTTGAATAGATTAGCTTATATACTTTGGAATTTGTTAAAAAAAGATTTTTATAAAAAAta
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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