Basic Information
VIS ID
TVIS30011614
Fusion event
HIV-EMSY integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76164620/76453576 (Hg38)
End
76164620/76453576 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
EMSY
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-657 ; hsa-mir-329-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p
Nearest miRNA
hsa-mir-10392/Upstream/1118390; hsa-let-7a-2/Downstream/2948446;
Nearest TSS
ENST00000527297/Upstream/6637; ENST00000531998/Downstream/59821;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/7793, chr11-CpG: 92/Downstream/216829
Nearest cancer related gene
EMSY(OG, No orient, 0)
Upstream sequence
GAGTCTTTTAAGTAACAATATCTCTATACTCAGGGATCCTGATCATAGCAGTAAAAGTGATATTAACTGTTTATTCAGTTGGGTTTTTTTTTGCATTTGG
Downstream sequence
TTAGGCAAGCTTTAAGTACTCAGGTCAAATCCTGTTACAATGTAATCTCTGTCTAACTAAAAATCACCACAATTTAGCAGATGATTCACTTACTTGAGGC
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
Curate