Basic Information
VIS ID
TVIS30012543
Fusion event
HIV-BRD4 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
15429114/15318303 (Hg38)
End
15429114/15318303 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
BRD4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-2110 ; hsa-mir-877-3p ; hsa-mir-455-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-544a ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-6731-3p ; hsa-mir-6832-3p ; hsa-mir-3938 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3613-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-4495 ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1306-5p
Nearest miRNA
hsa-mir-10395/Upstream/138953; hsa-let-7e/Downstream/131245;
Nearest TSS
ENST00000633603/Upstream/37852; ENST00000601005/Downstream/13603;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/79125, chr19-CpG: 154/Downstream/13147
Nearby gene
AKAP8(No orient, 35218)
Nearest cancer related gene
BRD4(OG, No orient, 0)
Upstream sequence
TAATAAAAGCCAAGACCAATGGTACATGAATGAGGGAAAACATCCATTGGCACATACAAGTTTAATCTTCAAACTATAGAGATTGGGGCGGGGGGGTGAA
Downstream sequence
GGAGTCTGTAATAGGTGCTATTCTTAGAAGTAATAAGAGTTCTTTTCCATCCTCTGACTCAACTCTGCCCCAATTACAGAAGTATGAATTATTCAAGTTT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
Curate