Basic Information
VIS ID
TVIS30013614
Fusion event
HIV-KMT2C integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152084136/152387051 (Hg38)
End
152084136/152387051 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/953412; hsa-mir-153-2/Downstream/5187285;
Nearest TSS
ENST00000635602/Upstream/74755; ENST00000564834/Downstream/48748;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/20056, chr7-CpG: 219/Downstream/48081
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
ATACATTTTATATAGAATTTTGTTAAGTATTCCTTAAAATATCACTTTAATATGCCATAAGAATAACCACAGAATAGTGTTACTTTAAAGTAAAAAGATA
Downstream sequence
TAAATAGGAGCCCAAAATGTTAAGTGGGGTTTTACAATCAAGAAGACACACCAGAATAAGATATTTTTTAAATACCATGTACATTAAAGAGATCATACTT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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