Basic Information
VIS ID
TVIS30013701
Fusion event
HIV-MLLT3 integration
Validated
No
Detection method
QiaQuick PCR and Sequencing
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2013
PubMed ID
23953889
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
20606463/20606464 (Hg38)
End
20606463/20606464 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
MLLT3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3924 ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-5692c ; hsa-mir-5692b
Nearest miRNA
hsa-mir-101-2/Upstream/104122; hsa-let-7a-1/Downstream/109641;
Nearest TSS
ENST00000422679/Upstream/194502; ENST00000604036/Downstream/15409;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/671635, chr9-CpG: 167/Downstream/13961
Nearest cancer related gene
MLLT3(OG, No orient, 0)
Upstream sequence
AAAACTCAGAAAAAAACAGTAATTTCTAAAGCAGAGGTTCCTGCCGTACCCCCTTCACCCACCCGTACTTTTAAAACAGCTACATAAACAAAGTAATAAG
Downstream sequence
TGCTCAATTTCAGAGAGAATTACATTATACTCCATTTGAACAGGCTACAAAGTACTTTTATTTGAAAAGCTGCTTGTGCTCTGTTATAAACAATTTTACT
Reference
Sherrill-Mix, S., et al. HIV latency and integration site placement in five cell-based models.2013, Retrovirology 10: 90.
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