Basic Information
VIS ID
TVIS30013875
Fusion event
HIV-JAK1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
Nontumor
Disease
AIDS dementia (AD)
Quality evaluation
Normal
Reported year
2003
PubMed ID
12843741
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
65483334/65017651 (Hg38)
End
65483334/65017651 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
JAK1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-128-3p ; hsa-mir-20a-5p ; hsa-mir-23b-3p ; hsa-mir-15b-5p ; hsa-mir-9-5p ; hsa-mir-107 ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-373-3p
Nearest miRNA
hsa-mir-12132/Upstream/437728; hsa-mir-101-1/Downstream/40104;
Nearest TSS
ENST00000473358/Upstream/13564; ENST00000470888/Downstream/50086;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/14506, chr1-CpG: 169/Downstream/48936
Nearby gene
LINC01359(No orient, 15175)
Nearest cancer related gene
JAK1(OG, No orient, 0)
Upstream sequence
tcattcaacaactgcagaaaaaaattctgaagtccacacagaatatttcaaaaatggactcatacatagtcattaaaacaagcctcaacagatattaaag
Downstream sequence
gattaatacagaggatgttttctgacctaaagtgatctaactataaatcaataataaaaaggtaaacagagcatctccatgtttggaaaattaaaaccat
Reference
Mack, K. D., et al. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr ,2003,33(3): 308-320.
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