Basic Information
VIS ID
TVIS30013879
Fusion event
HIV-SDHB integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
Nontumor
Disease
AIDS dementia (AD)
Quality evaluation
Normal
Reported year
2003
PubMed ID
12843741
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
17362548/17036053 (Hg38)
End
17362548/17036053 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
SDHB
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-12136/Upstream/177032; hsa-mir-101-1/Downstream/241836;
Nearest TSS
ENST00000473358/Upstream/12893; ENST00000634972/Downstream/8824;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/23966, chr1-CpG: 31/Downstream/17908
Nearest cancer related gene
SDHB(TSG, No orient, 0)
Upstream sequence
AAAAAGTCAAAGTCCTCTCTTTAAGCTGTTTCATGCTAAATTTCCTAATAGGTAGGGCTCATTAAAGAGTACAACATAAATTTTCTCAGATTTTACATAG
Downstream sequence
ATACcaaaattgtttgatattctgggtcccttgcatttctataagatttttagaatcaacttgtcaacttctgcagaaaaggcaggtgggattttgatgg
Reference
Mack, K. D., et al. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr ,2003,33(3): 308-320.
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