Basic Information
VIS ID
TVIS30013880
Fusion event
HIV-CHD2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
Nontumor
Disease
AIDS dementia (AD)
Quality evaluation
Normal
Reported year
2003
PubMed ID
12843741
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
93556469/93013239 (Hg38)
End
93556469/93013239 (Hg38)
Orient
+
Location type
Intronic
Target gene
CHD2
miRNAs that regulate target gene
hsa-mir-450a-5p ; hsa-mir-196b-5p ; hsa-mir-378a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10393/Upstream/108764; hsa-mir-1302-10/Downstream/3320022;
Nearest TSS
ENST00000557528/Upstream/811; ENST00000555297/Downstream/49830;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/108646, chr15-CpG: 34/Downstream/31633
Upstream sequence
cactcaggagtatttgttATGCTGTGCCCAGTGCTGTGTTGGCCTGTGAAGCAGCACCCTCAAGTAGTTGATGATTTAATTTTACATGGAAGAATATGTT
Downstream sequence
ATAGCAGTAACATACAGGAATCATATACTAATAAGCATTATAAAAAGTCTATAAATGGATAGTCCGGAAAGGCCCCAGGAGGGAATGAAATAGTTAGGAA
Reference
Mack, K. D., et al. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr ,2003,33(3): 308-320.
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