Basic Information
VIS ID
TVIS30013886
Fusion event
HIV-MRTFB integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
Nontumor
Disease
AIDS dementia (AD)
Quality evaluation
Normal
Reported year
2003
PubMed ID
12843741
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14310479/14216622 (Hg38)
End
14310479/14216622 (Hg38)
Orient
+
Location type
Intronic
Target gene
MRTFB
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-607 ; hsa-mir-3156-3p ; hsa-mir-3671 ; hsa-mir-4433a-5p ; hsa-mir-3907 ; hsa-mir-3145-3p ; hsa-mir-139-5p ; hsa-mir-4735-5p ; hsa-mir-4301 ; hsa-mir-181a-2-3p ; hsa-mir-4762-5p ; hsa-mir-5002-5p ; hsa-mir-5588-3p ; hsa-mir-32-3p ; hsa-mir-6715b-3p ; hsa-mir-1256 ; hsa-mir-8076 ; hsa-mir-3688-3p ; hsa-mir-183-5p ; hsa-mir-190a-5p ; hsa-mir-190b ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1225/Upstream/1496251; hsa-mir-11401/Downstream/87345;
Nearest TSS
ENST00000527434/Upstream/16292; ENST00000571770/Downstream/30789;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/144823, chr16-CpG: 54/Downstream/68845
Nearest cancer related gene
MRTFB(OG, No orient, 0)
Upstream sequence
CTGTATACAACCATTAATTACTGTATATTATAGTTGAATGTTCCTAACAGACACAAGGATATGTATTCAGAAATAAACCCAAATTCTTAATTATGATGAC
Downstream sequence
CGACCGAGACACAGGGGATCAATTCAAGAATATGAATGATAGCTCTTCCCATTGACCTCTGCAGAGAAGCTTATAACCCTAAGAGGCAGTGTCTCCCTTC
Reference
Mack, K. D., et al. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr ,2003,33(3): 308-320.
Curate