Basic Information
VIS ID
TVIS30013900
Fusion event
HIV-PIK3C2A integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
Tumor
Disease
AIDS-associated lymphoma (AAL)
Quality evaluation
Normal
Reported year
2003
PubMed ID
12843741
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17163574/17142027 (Hg38)
End
17163574/17142027 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PIK3C2A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-22-3p ; hsa-mir-21-5p ; hsa-let-7i-5p ; hsa-mir-182-5p ; hsa-mir-26a-5p ; hsa-mir-544a ; hsa-mir-6878-3p ; hsa-mir-378a-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6778-3p ; hsa-mir-4454 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-212-5p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6813-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-518a-5p ; hsa-mir-218-1-3p
Nearest miRNA
hsa-mir-210/Upstream/1172406; hsa-let-7a-2/Downstream/1245760;
Nearest TSS
ENST00000527297/Upstream/64240; ENST00000620945/Downstream/27714;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/64068, chr11-CpG: 68/Downstream/65437
Upstream sequence
tccagggttttggtctgagcaaatggaagacaaagttgccatttattaaaaagggaaataatgaggtcaagttatgcatgtgtagggaagggggtatatg
Downstream sequence
aggtatctctgtaccttcctctcagtttgctctgaacctaacattgctctcaaaaaataaactcttaaaaagagaaaggaaaggtcgatggatgaataga
Reference
Mack, K. D., et al. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr ,2003,33(3): 308-320.
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