Basic Information
VIS ID
TVIS30013909
Fusion event
HIV-RUNX2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
Cell line
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2003
PubMed ID
12843741
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
45481312/45513575 (Hg38)
End
45481312/45513575 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
RUNX2
miRNAs that regulate target gene
hsa-mir-135b-5p ; hsa-mir-155-5p ; hsa-mir-335-5p ; hsa-mir-203a-3p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-204-5p ; hsa-mir-433-3p ; hsa-mir-338-3p ; hsa-mir-124-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-505-5p ; hsa-mir-484 ; hsa-mir-30b-5p ; hsa-mir-218-5p ; hsa-mir-23b-3p ; hsa-mir-34c-5p ; hsa-mir-30c-5p ; hsa-mir-205-5p ; hsa-mir-320a ; hsa-mir-135a-5p ; hsa-mir-222-3p ; hsa-mir-221-5p ; hsa-mir-628-3p ; hsa-mir-103a-3p ; hsa-mir-30a-3p ; hsa-mir-376c-3p
Nearest miRNA
hsa-mir-10398/Upstream/315805; hsa-mir-10524/Downstream/6630774;
Nearest TSS
ENST00000381078/Upstream/90998; ENST00000321037/Downstream/63195;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/89666, chr6-CpG: 84/Downstream/149674
Nearest cancer related gene
RUNX2(TSG, No orient, 0)
Upstream sequence
GTTGCATCACTGACAAGCTGAAGCTCCACCAGCAGGCTTGCGGGTTTTGATTAGTTCAGACTCCTTTATTTCTTTCAACTTGGGAGGAGGGAAGGCTTTG
Downstream sequence
TTTCTCAAGCAAATAGCAGGAAAGGGCTCTCTGGTCCTAGTGCCTCACATTTTCTGCAGCAGATGGACTCCCATGGGGGTGAGTAGGGAAAGAAGAGGGG
Reference
Mack, K. D., et al. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr ,2003,33(3): 308-320.
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