Basic Information
VIS ID
TVIS30013971
Fusion event
HIV-TOP2A integration
Validated
Yes
Detection method
invPCR+RT-PCR
Data source
download(RID)
Sample type
T cell
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2004
PubMed ID
15163705
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
38563322/40407070 (Hg38)
End
38563322/40407070 (Hg38)
Orient
-
Location type
Intronic
Target gene
TOP2A
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-21-5p ; hsa-mir-1226-3p ; hsa-mir-708-5p ; hsa-mir-186-5p ; hsa-mir-7-5p ; hsa-mir-218-5p ; hsa-mir-203a-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-3668 ; hsa-mir-4524b-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-561-3p
Nearest miRNA
hsa-mir-1180/Upstream/213407; hsa-mir-10226/Downstream/1110094;
Nearest TSS
ENST00000595228/Upstream/7809; ENST00000269593/Downstream/10635;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/43058, chr17-CpG: 47/Downstream/10394
Nearby gene
NBR2(No orient, 12671)
Junction sequence
AAGGTGGACC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Han, Y., et al. Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. J Virol ,2004,78(12): 6122-6133.
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