Basic Information
VIS ID
TVIS30013986
Fusion event
HIV-ITCH integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
33058716/34470911 (Hg38)
End
33058716/34470911 (Hg38)
Orient
+
Location type
Intronic
Target gene
ITCH
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-324-3p ; hsa-mir-127-5p ; hsa-mir-541-5p ; hsa-mir-485-5p ; hsa-mir-20a-5p ; hsa-mir-302c-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-3143 ; hsa-mir-8068 ; hsa-mir-1252-5p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-543 ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-214-5p ; hsa-mir-3653-3p ; hsa-mir-6796-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/4493; hsa-mir-1-1/Downstream/519465;
Nearest TSS
ENST00000382410/Upstream/25550; ENST00000461661/Downstream/590;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/106748, chr20-CpG: 43/Downstream/45396
Upstream sequence
tggattcaaatgatcctcctgcctcatcttccccaagtgctgggattacaggcataaaccagcatgcccggACACCAGCCATTTTTATATCTATCGTTTG
Downstream sequence
ATATAACTGACTTTGATAGATAAATACATGTTCATACATACATGAACATGTCCATACATAGATGTTATATTCAGTGTTTTTTTCAGATGTGATCAACTAT
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate