Basic Information
VIS ID
TVIS30014005
Fusion event
HIV-COG5 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
106924361/107283916 (Hg38)
End
106924361/107283916 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
COG5
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-320a ; hsa-mir-3978 ; hsa-mir-4261 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-610 ; hsa-mir-181a-2-3p ; hsa-mir-497-3p
Nearest miRNA
hsa-mir-10525/Upstream/4812385; hsa-mir-10399/Downstream/7369429;
Nearest TSS
ENST00000635602/Upstream/25296; ENST00000473300/Downstream/186102;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/114032, chr7-CpG: 59/Downstream/279753
Upstream sequence
AAATGCACCTCCCATAAAAATGTAACTCTATATTAAGAAAAAGAAAATAATTTGTTTCACAACGTACATATTTACCAATATATTTCATAATTAAACATTC
Downstream sequence
AGGACCATAGTAACCtttttttttttgagacgtagtctcactctgttgtcctggctggagtgcaacggcgcaatcttggctcactgcaacctctacctcc
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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