Basic Information
VIS ID
TVIS30014026
Fusion event
HIV-PPP6R3 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68288628/68521160 (Hg38)
End
68288628/68521160 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
PPP6R3
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-615-3p ; hsa-mir-20a-5p ; hsa-mir-624-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-552-5p ; hsa-mir-652-5p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548t-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548ao-5p ; hsa-mir-548ax ; hsa-mir-548az-5p ; hsa-mir-7854-3p ; hsa-mir-759 ; hsa-mir-3174 ; hsa-mir-3678-3p ; hsa-mir-3944-5p ; hsa-mir-4519 ; hsa-mir-2467-3p ; hsa-mir-5586-3p ; hsa-mir-1273h-3p ; hsa-mir-623 ; hsa-mir-542-3p ; hsa-mir-107 ; hsa-mir-1909-5p ; hsa-mir-2277-3p ; hsa-mir-6780b-3p ; hsa-mir-6841-3p ; hsa-mir-4780 ; hsa-mir-5190 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4696 ; hsa-mir-5585-5p ; hsa-mir-32-3p ; hsa-mir-548n ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-424-5p ; hsa-mir-4264 ; hsa-mir-4291 ; hsa-mir-4704-3p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10392/Upstream/476203; hsa-let-7a-2/Downstream/562016;
Nearest TSS
ENST00000527297/Upstream/1525; ENST00000531244/Downstream/14251;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/60052, chr11-CpG: 28/Downstream/149011
Upstream sequence
cgcgtccggccTCACAGAGTTTTATTATTGTTCTTTGTATTTGAATTCACGTCTTCTGGGGCTCAGCTTTCTTCCTGCCTTTTTTGTCAAACCACCTTGG
Downstream sequence
ATTGTTCCAGTTCCCTTGTGATCACTCCTTTGTGAACTCTCAGAGCATCTCATTAAGTTATTTTAGGATTATTTTTTTCTCTTAACTACATTTTAAGTAT
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate