Basic Information
VIS ID
TVIS30014070
Fusion event
HIV-SLK integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
105737093/103977335 (Hg38)
End
105737093/103977335 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLK
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-let-7c-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/582934; hsa-mir-202/Downstream/70754;
Nearest TSS
ENST00000439456/Upstream/10134; ENST00000474260/Downstream/30863;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/9667, chr10-CpG: 46/Downstream/144356
Upstream sequence
aaataaatttattaGAAAACAAAGGTTGAAAATAAACAGAATGAACAAACTCTATTTTTGCTTGCCCCAAAACCTCAATAAAAACTGTTATCTggccagg
Downstream sequence
tgcagtgactcatgcctgtaatcccagcactttataagtttgaggcagtaggattgcttgagcccaggaattcaagaacagcctgggcaacatagcgaga
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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