Basic Information
VIS ID
TVIS30014074
Fusion event
HIV-MARS integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57909229/57515446 (Hg38)
End
57909229/57515446 (Hg38)
Orient
+
Location type
Intronic
Target gene
MARS
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-505-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-339-5p ; hsa-mir-185-5p ; hsa-mir-222-3p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-541-5p
Nearest miRNA
hsa-mir-1228/Upstream/2696; hsa-let-7i/Downstream/3717;
Nearest TSS
ENST00000382841/Upstream/263; ENST00000552255/Downstream/5034;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/27194, chr12-CpG: 19/Downstream/4578
Upstream sequence
GAGCCAGCCTCTCTTAAAATTGATACTCTTGCCATGCAGCTTTTGGAGTGGGTGAGAGAAGACCTAACATCTCTCCAGTGTTACTTTGGTCATGGGACTC
Downstream sequence
CTAAGTTTCTGATATAAAGTCCTTGGTAGTCGTTCACAAGTCCGGAATTATCTGTACATCTTCATTGTTCTTCATGCCAGAAACCAGAACCTGGCACACA
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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