Basic Information
VIS ID
TVIS30014101
Fusion event
HIV-BIRC6 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32687141/32462073 (Hg38)
End
32687141/32462073 (Hg38)
Orient
-
Location type
Intronic
Target gene
BIRC6
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-218-5p ; hsa-mir-615-3p ; hsa-mir-34a-5p ; hsa-let-7a-5p ; hsa-mir-342-3p
Nearest miRNA
hsa-mir-1301/Upstream/4465624; hsa-mir-10b/Downstream/70080;
Nearest TSS
ENST00000437798/Upstream/18647; ENST00000462504/Downstream/10919;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/103876, chr2-CpG: 20/Downstream/165867
Upstream sequence
ggttctgatcctagttctactgtgagtttacaggttaatttctctgagccttctttacttaatcagcaaaaaaataaaaataAAAAAAAAAAGGTGGGGG
Downstream sequence
GGATCATGATGCCTGGGCCATAAAGTTGCCCATAAAGTGAATTGTAGTTATTCTTTAAAACAATGCCACATGGTAATGCATACTAAATATTTGCTATTCT
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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