Basic Information
VIS ID
TVIS30014106
Fusion event
HIV-SMURF2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
62612983/64616865 (Hg38)
End
62612983/64616865 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMURF2
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-630 ; hsa-mir-511-5p ; hsa-mir-203a-3p ; hsa-mir-4670-3p ; hsa-mir-93-3p ; hsa-mir-382-5p ; hsa-mir-431-5p ; hsa-mir-526b-5p ; hsa-mir-4635 ; hsa-mir-665 ; hsa-mir-4495 ; hsa-mir-3667-5p ; hsa-mir-6807-5p ; hsa-mir-6872-3p ; hsa-mir-378a-5p ; hsa-mir-4454 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-186-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p
Nearest miRNA
hsa-mir-10226/Upstream/115552; hsa-mir-1250/Downstream/163894;
Nearest TSS
ENST00000595228/Upstream/18420; ENST00000577938/Downstream/43997;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/109417, chr17-CpG: 112/Downstream/44426
Upstream sequence
CCTTTTAAAGAATCTTACTCTAGGCTggcacagtggctcatgcctgtaatcccaacagtttgagacgtctaggcgggctgatggtttgagcctaggagtt
Downstream sequence
cgagaccagtctgggcaacagggcaaaaccccatctctacaaaaatatacaaaaaaagaaaaaaaaatagcccggcatggtggtgtgtgcctgtagtccc
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate