Basic Information
VIS ID
TVIS30014108
Fusion event
HIV-TYK2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10468402/10357726 (Hg38)
End
10468402/10357726 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
TYK2
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-1227/Upstream/127241; hsa-let-7e/Downstream/45732;
Nearest TSS
ENST00000633603/Upstream/642; ENST00000586275/Downstream/175;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3475, chr19-CpG: 57/Downstream/22617
Upstream sequence
GGCCCACCTGCTGGTAGCCCAGAGAGACTTGAAGTCACGAGGCCAGAAGGGATGCAGCTTTGAGCTCTGATTCTGTCCTCTGGATTTCTTGGAGGGGCCC
Downstream sequence
CCACTGCGGGGAGGGCCCAAGGGTCTCCTAGACATACCTCGGAGGGACTGCGGCTCTGCAGAGGGGCCTCTCCGTCAAAGCAGATCTCCAGGAGGGTGGC
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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