Basic Information
VIS ID
TVIS30014128
Fusion event
HIV-NCOA2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
71312554/70400319 (Hg38)
End
71312554/70400319 (Hg38)
Orient
-
Location type
Intronic
Target gene
NCOA2
miRNAs that regulate target gene
hsa-mir-137 ; hsa-mir-193b-3p ; hsa-mir-544a ; hsa-mir-1185-5p ; hsa-mir-6864-5p ; hsa-mir-4471 ; hsa-mir-8059 ; hsa-mir-539-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-3120-3p ; hsa-mir-429 ; hsa-mir-200b-3p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-124-1/Upstream/6021062; hsa-mir-10400/Downstream/4148224;
Nearest TSS
ENST00000518652/Upstream/154944; ENST00000520259/Downstream/1760;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/327666, chr8-CpG: 251/Downstream/1591
Upstream sequence
TTTCTACCCTCCTGCTTCAGTATACTGACATCTAAAAGTCAAAGAACTCCTCTGTTTAAGACTGAAATTCCCAGGAGGAAGGAAGCTCAGATCCAGTCTG
Downstream sequence
AGAGCACACAATGGAATCACAGCTGACGATGCACATCTTTTTCTAGATGTCTCCATATGCTTGAGAGGTTTTTTTCCCCCCAAGCCAGCCATTAGGAGAC
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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