VISDB - VIS Detail

Basic Information

VIS ID

TVIS30014152

Fusion event

HIV-LIX1L integration

Validated

Yes

Detection method

invPCR

Data source

download(RID)

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Normal

Reported year

2007

PubMed ID

17262715

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

q21.1

Reference genome

GRCh37/hg19

Start

145488885/145946200 (Hg38)

End

145488885/145946200 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA1F

Target gene

LIX1L

miRNAs that regulate target gene

hsa-mir-93-5p ; hsa-mir-503-5p ; hsa-mir-100-5p ; hsa-let-7a-5p ; hsa-mir-665 ; hsa-mir-510-5p ; hsa-mir-25-5p ; hsa-mir-5192 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6087 ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-1247-3p ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-4314 ; hsa-mir-4695-5p ; hsa-mir-1257 ; hsa-mir-3650 ; hsa-mir-4790-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3192-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-1298-3p ; hsa-mir-4693-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-661 ; hsa-mir-4252 ; hsa-mir-4486 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-6818-3p ; hsa-mir-4684-5p ; hsa-mir-4662a-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4755-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-6732-3p ; hsa-mir-548c-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p

Nearest miRNA

hsa-mir-101-1/Upstream/95555; hsa-mir-1182/Downstream/2388279;

Nearest TSS

ENST00000473358/Upstream/5004; ENST00000616257/Downstream/11801;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/18696, chr1-CpG: 46/Downstream/11406

Upstream sequence

cttgaactctggaggcggagattgcagtgatctgagattgcaccacggcactctagcctgggcaacagagtgagactctggctcaaaaaaaaaaaaaaaa

Downstream sequence

agaaCTTCAGTCATTTCAGAGAAATAACTATATACCCAAGATGACAAATGTTTATGCTTTCACTTGTTtttttttgtttttttgtttttttgttttttga

Reference

Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.