Basic Information
VIS ID
TVIS30014165
Fusion event
HIV-LEMD2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
33746300/33778523 (Hg38)
End
33746300/33778523 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
LEMD2
miRNAs that regulate target gene
hsa-mir-23a-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-629-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-570-3p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-5088-3p ; hsa-mir-8060 ; hsa-mir-21-3p ; hsa-mir-3591-3p ; hsa-mir-4258 ; hsa-mir-7108-3p
Nearest miRNA
hsa-mir-1236/Upstream/80289; hsa-mir-10398/Downstream/120612;
Nearest TSS
ENST00000381078/Upstream/184; ENST00000526556/Downstream/1776;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/6564, chr6-CpG: 127/Downstream/9763
Upstream sequence
GCTCCAAGGAGAGGCAGTGCAAGCCCCACTTCAAACAGGAGGAAGCGAAGGAAAGTGGGGACGCAAGGCCTCTACTTGCTTATAGAATAGGCTTGGTATC
Downstream sequence
CTGGCTGCATTCTTTCCAGAAATTTCCCACATTGGCTACTTAGAATGAATAAAGCTTTAAAGACGGCAGCAGGCTTGAACCCCTACCGCTAAAGCAACGT
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate