Basic Information
VIS ID
TVIS30014167
Fusion event
HIV-GNB1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
1754772/1823333 (Hg38)
End
1754772/1823333 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
GNB1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-16-5p ; hsa-mir-589-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-let-7b-5p ; hsa-mir-218-5p ; hsa-mir-493-3p ; hsa-mir-3064-3p ; hsa-mir-3138 ; hsa-mir-1227-3p ; hsa-mir-891a-5p ; hsa-mir-4795-5p ; hsa-mir-6838-5p ; hsa-mir-6501-3p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-2278 ; hsa-mir-582-5p ; hsa-mir-889-3p ; hsa-mir-324-5p ; hsa-mir-302a-5p ; hsa-mir-1277-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-5692a ; hsa-mir-4520-3p ; hsa-mir-874-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-6125 ; hsa-mir-3120-3p ; hsa-mir-1287-5p ; hsa-mir-2392 ; hsa-mir-3135b ; hsa-mir-3907 ; hsa-mir-3928-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4524b-3p ; hsa-mir-4768-3p ; hsa-mir-766-5p
Nearest miRNA
hsa-mir-12136/Upstream/483625; hsa-mir-101-1/Downstream/1304642;
Nearest TSS
ENST00000473358/Upstream/4947; ENST00000412228/Downstream/2221;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/40631, chr1-CpG: 199/Downstream/66633
Upstream sequence
tgtctccagaaaaaaaaaaaaaaaaaaaaaaaaaTCTGATTTCTATAAGATGAAATATAGTCTCAAAAGCAGGTGGTAAAGAGCTGAGAGTGTTCTGAAC
Downstream sequence
CCCCCCAAAAACCCAGTTAGATTATTATTAAATAACAACACTTTGCTTTTCTTTTTTACTTGCCAAAAACCATGCTGACTTAAAATGAACAGCAGAAGCT
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate