Basic Information
VIS ID
TVIS30014187
Fusion event
HIV-ELL integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
18610072/18499262 (Hg38)
End
18610072/18499262 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ELL
miRNAs that regulate target gene
hsa-mir-769-3p ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-27a-5p ; hsa-mir-3065-5p ; hsa-mir-3131 ; hsa-mir-3153 ; hsa-mir-4270 ; hsa-mir-4327 ; hsa-mir-4417 ; hsa-mir-4441 ; hsa-mir-4668-5p ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-5004-5p ; hsa-mir-541-3p ; hsa-mir-611 ; hsa-mir-6134 ; hsa-mir-654-5p ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-6754-5p ; hsa-mir-6785-5p ; hsa-mir-6877-5p ; hsa-mir-6883-5p ; hsa-mir-7-1-3p ; hsa-mir-7-2-3p ; hsa-mir-7706
Nearest miRNA
hsa-mir-10395/Upstream/112628; hsa-let-7e/Downstream/935801;
Nearest TSS
ENST00000633603/Upstream/23329; ENST00000597837/Downstream/22805;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/37453, chr19-CpG: 116/Downstream/22226
Nearest cancer related gene
ELL(OG, No orient, 0)
Upstream sequence
ATCCCAGCAGGGATGGGAGGGCTCAACAGGAATGACACAAGGGCCACCAGCAGCTGCTGGGAAGTGAAAGCAAAACTTCTATCTTGgggcccaagaactg
Downstream sequence
agatcagaagattcacttccaacttatgatctgccatttaaaagctgtgtgacctcagtaagacacttaacctctctgggctttgtcacacagggtgatg
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate