Basic Information
VIS ID
TVIS30014205
Fusion event
HIV-SPATS2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
49804993/49411210 (Hg38)
End
49804993/49411210 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
SPATS2
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-103a-3p ; hsa-mir-296-3p ; hsa-let-7a-5p ; hsa-mir-3154 ; hsa-mir-6873-3p ; hsa-mir-4680-3p ; hsa-mir-5187-3p ; hsa-mir-4427 ; hsa-mir-3921 ; hsa-mir-4653-5p ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-7110-3p ; hsa-mir-6817-3p ; hsa-mir-4639-3p ; hsa-mir-8485 ; hsa-mir-603 ; hsa-mir-1324 ; hsa-mir-4668-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3613-3p ; hsa-mir-3184-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/639173; hsa-let-7i/Downstream/822932;
Nearest TSS
ENST00000382841/Upstream/43663; ENST00000549045/Downstream/49669;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/21800, chr12-CpG: 191/Downstream/126630
Upstream sequence
CCCATACTGATATTTAAAAtcagccacattatgggttaaatagatgtttgcatgttgacctTCTCTTTCCTTTTAGTTTCCCATCTAATGTAGTAATAGA
Downstream sequence
AAAGTTTATTGTTgttagcatactcagtcctcttgccatgtaatgcccttggtcatctcaggacacatcaaagagaacacaccagcaagaaggctcccac
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate