Basic Information
VIS ID
TVIS30014207
Fusion event
HIV-PLEKHA5 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
19311648/19158714 (Hg38)
End
19311648/19158714 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLEKHA5
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-25-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1485320; hsa-let-7i/Downstream/5053707;
Nearest TSS
ENST00000382841/Upstream/28004; ENST00000534979/Downstream/46548;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/27747, chr12-CpG: 34/Downstream/147609
Upstream sequence
ACCTGCTTTGGTATTACCTCACTGCCATCTGACTGTATCCCTGCCTTTCCTGATTTCTGTGGCTATAGTAGAAGTCTTGTGGAGTTTGTGGAGTTTTTGA
Downstream sequence
AGTTTGTGTAGTTTTGAAGTTTTGAGAACAGACCTGTTTGTAGTTATGATCCAGTGGCATAAGCTGACCTCAGGATATACCAGCTTGCTTTATTAGTGAC
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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