Basic Information
VIS ID
TVIS30014218
Fusion event
HIV-POLR2A integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
7389764/7486445 (Hg38)
End
7389764/7486445 (Hg38)
Orient
-
Location type
Intronic
Target gene
POLR2A
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-744-5p ; hsa-mir-454-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-324-5p ; hsa-mir-320a ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-93-5p ; hsa-mir-17-3p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1260b ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1253/Upstream/263066; hsa-mir-10226/Downstream/601611;
Nearest TSS
ENST00000595228/Upstream/1825; ENST00000576952/Downstream/11336;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1438, chr17-CpG: 50/Downstream/62388
Upstream sequence
TGGCTGGAAAGAATGGAGTTAAGTGGCTGTTTGTGGATAGAGACCATTTTTGCTGGGAGAAAGTTCAGCTATGTCAGGAGTCAGAACGTCCTGacctcac
Downstream sequence
accataccacagaatcagttccagatgaagttaagacttaaacctaaaaaaacccataaagcactagaaaaaaaatagaaggcttttgcagggctgatac
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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