Basic Information
VIS ID
TVIS30014255
Fusion event
HIV-PRKCH integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
61831805/61365087 (Hg38)
End
61831805/61365087 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
PRKCH
miRNAs that regulate target gene
hsa-mir-376c-3p ; hsa-mir-432-5p ; hsa-mir-376a-3p ; hsa-mir-493-3p ; hsa-mir-4531 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-3938 ; hsa-mir-3675-3p ; hsa-mir-216b-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-208a/Upstream/716376; hsa-mir-1185-1/Downstream/2729937;
Nearest TSS
ENST00000550708/Upstream/4013; ENST00000557473/Downstream/25607;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/42338, chr14-CpG: 112/Downstream/330042
Upstream sequence
TAGTCTCCAAGGTAGAGCAGTTTGAGGGAGTGGCCATGGGAATGGCTGAGAGAAGTGGCCTGGAAGTGAAGGCCAGTGAGGTAGAGGATAGCCCACAGGG
Downstream sequence
AAACCTTTGTAGAAATGGGACTTTTATTCCACTTGTAAGATTCACACTGAATTATAGCATTGGATGTGTAGAATAAGAAACTTCATTTTGGTGTTTGAGA
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate