Basic Information
VIS ID
TVIS30014259
Fusion event
HIV-DDX17 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
38886872/38490867 (Hg38)
End
38886872/38490867 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
DDX17
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-155-5p ; hsa-mir-744-5p ; hsa-mir-18a-3p ; hsa-mir-331-3p ; hsa-mir-106b-5p ; hsa-mir-27b-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-378c ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-432-3p ; hsa-mir-377-3p ; hsa-mir-218-5p ; hsa-mir-539-3p ; hsa-mir-6883-3p ; hsa-mir-3606-5p ; hsa-mir-3613-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-1266-3p ; hsa-mir-454-5p ; hsa-mir-190a-3p ; hsa-mir-5690
Nearest miRNA
hsa-mir-1286/Upstream/502014; hsa-let-7a-3/Downstream/2323016;
Nearest TSS
ENST00000624155/Upstream/1906; ENST00000475924/Downstream/2904;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/22609, chr22-CpG: 145/Downstream/14681
Upstream sequence
AGGCAGCAAACAAAGGGGCCCAAAACAAGCACTGATGTTGAGTAACAAGAAACAGACTCGGGTACCTTCCCTCTCCCCTCACTTGGATGAGTGGGGGTGG
Downstream sequence
GATGAAGAGTCTAAGTTATTCTAATGGTAGCCAATTAATTTGGTTTAGAAATGCAAGGGGACATGGAGCAAATATTTTTAATTGTCTAGGCAAGATGCAC
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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