Basic Information
VIS ID
TVIS30014260
Fusion event
HIV-IL2RB integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
37547781/37151741 (Hg38)
End
37547781/37151741 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
IL2RB
miRNAs that regulate target gene
hsa-mir-6834-5p ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-6747-5p ; hsa-mir-4455 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-4300 ; hsa-mir-5591-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-6732-5p
Nearest miRNA
hsa-mir-1286/Upstream/864834; hsa-let-7a-3/Downstream/692531;
Nearest TSS
ENST00000624155/Upstream/1751; ENST00000419128/Downstream/15016;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/53607, chr22-CpG: 33/Downstream/30451
Nearby gene
IL2RB(No orient, 1819)
Upstream sequence
catgtcctaaagagtttccccaatgttccttttagtagtttcatagtttgaggtctcagatttaagtctttaatccatttggatttgatttttgtatatg
Downstream sequence
aagagagatgagggtctagtttcattcttctgcatatggatatccagttttcccagcaacatttattgaaaagactggcctttccccaaaggtatgtttt
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate